Severe adverse cutaneous drug eruptions: epidemiological and clinical features
Identifieur interne : 001509 ( Main/Exploration ); précédent : 001508; suivant : 001510Severe adverse cutaneous drug eruptions: epidemiological and clinical features
Auteurs : Inès Zaraa [Tunisie] ; Meriem Jones [Tunisie] ; Sondes Trojjet [Tunisie] ; Rym Cheikh Rouhou [Tunisie] ; Dalenda El Euch [Tunisie] ; Mourad Mokni [Tunisie] ; Amel Ben Osman [Tunisie]Source :
- International Journal of Dermatology [ 0011-9059 ] ; 2011-07.
English descriptors
- Teeft :
- Acdr, Adverse drug reactions, Agep, Antibiotic, Anticonvulsant, Arch dermatol, Clin, Clin pharm, Cutaneous, Cutaneous drug reactions, Cutaneous reactions, Dermatol, Dermatology, Dermatology department, Drug hypersensitivity syndrome, Drug intake, Drug reaction, Drug reactions, Eruption, Exanthematous pustulosis, Female ratio, Higher frequency, International journal, International society, Nonsteroidal drugs, Pharmacoepidemiol drug, Pharmacology, Pharmacovigilance investigation, Pilot study, Rabta, Rabta hospital, Severe acdr, Severe cutaneous, Severe forms, Severity markers, Severity signs, Therapeutics, Toxic epidermal necrolysis, Tunis, Visceral involvement, Zaraa.
Abstract
Introduction Adverse cutaneous drug reactions (ACDR) are common, and some can be lethal. The aim of our study was to discuss the epidemiological and clinical features of severe ACDR. Materials and methods We retrospectively analyzed 100 cases of ACDR from 1981 to 2007, collected in the Department of Dermatology of the La Rabta Hospital in Tunis, which is located in the north of Tunisia. Severity was defined on three criteria: hospitalization; visceral involvement; and severity markers. Results Characteristics of the 54 included cases were: women (70%); mean age: 44.8 years; responsible drugs: anticonvulsants (28%), antibiotics (28%), and nonsteroidal anti‐inflammatory drugs (15%). The most common dermatoses were maculopapular rash (50%). We observed fever (76%), lymphadenopathy (31.5%), eosinophilia (35%), and visceral involvement (50%). Twelve patients died directly related to the ACDR. Conclusion This study underlines the polymorphous clinical presentation of ACDR and the importance of researching some severity markers, which have important practical implications.
Url:
DOI: 10.1111/j.1365-4632.2010.04785.x
Affiliations:
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drug</term><term>Pharmacology</term><term>Pharmacovigilance investigation</term><term>Pilot study</term><term>Rabta</term><term>Rabta hospital</term><term>Severe acdr</term><term>Severe cutaneous</term><term>Severe forms</term><term>Severity markers</term><term>Severity signs</term><term>Therapeutics</term><term>Toxic epidermal necrolysis</term><term>Tunis</term><term>Visceral involvement</term><term>Zaraa</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Introduction Adverse cutaneous drug reactions (ACDR) are common, and some can be lethal. The aim of our study was to discuss the epidemiological and clinical features of severe ACDR. Materials and methods We retrospectively analyzed 100 cases of ACDR from 1981 to 2007, collected in the Department of Dermatology of the La Rabta Hospital in Tunis, which is located in the north of Tunisia. Severity was defined on three criteria: hospitalization; visceral involvement; and severity markers. Results Characteristics of the 54 included cases were: women (70%); mean age: 44.8 years; responsible drugs: anticonvulsants (28%), antibiotics (28%), and nonsteroidal anti‐inflammatory drugs (15%). The most common dermatoses were maculopapular rash (50%). We observed fever (76%), lymphadenopathy (31.5%), eosinophilia (35%), and visceral involvement (50%). Twelve patients died directly related to the ACDR. Conclusion This study underlines the polymorphous clinical presentation of ACDR and the importance of researching some severity markers, which have important practical implications.</div></front></TEI><affiliations><list><country><li>Tunisie</li></country><region><li>Gouvernorat de Tunis</li></region><settlement><li>Tunis</li></settlement></list><tree><country name="Tunisie"><region name="Gouvernorat de Tunis"><name sortKey="Zaraa, Ines" sort="Zaraa, Ines" uniqKey="Zaraa I" first="Inès" last="Zaraa">Inès Zaraa</name></region><name sortKey="Ben Osman, Amel" sort="Ben Osman, Amel" uniqKey="Ben Osman A" first="Amel" last="Ben Osman">Amel Ben Osman</name><name sortKey="Cheikh Rouhou, Rym" sort="Cheikh Rouhou, Rym" uniqKey="Cheikh Rouhou R" first="Rym" last="Cheikh Rouhou">Rym Cheikh Rouhou</name><name sortKey="El Euch, Dalenda" sort="El Euch, Dalenda" uniqKey="El Euch D" first="Dalenda" last="El Euch">Dalenda El Euch</name><name sortKey="Jones, Meriem" sort="Jones, Meriem" uniqKey="Jones M" first="Meriem" last="Jones">Meriem Jones</name><name sortKey="Mokni, Mourad" sort="Mokni, Mourad" uniqKey="Mokni M" first="Mourad" last="Mokni">Mourad Mokni</name><name sortKey="Trojjet, Sondes" sort="Trojjet, Sondes" uniqKey="Trojjet S" first="Sondes" last="Trojjet">Sondes Trojjet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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